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Parathyroid hormone–related protein was identified in the 1980s as a tumor product that had the ability to activate parathyroid hormone receptors and cause hypercalcemia.1 Parathyroid hormone–related protein resembles parathyroid hormone not only in terms of its genetic sequence but also in terms of its genetic structure and is thus a second member of the parathyroid hormone family.2 As expected of a protein that activates the parathyroid hormone receptor, parathyroid hormone–related protein causes hypercalcemia by increasing bone resorption and renal tubular resorption of calcium.3,4 Like parathyroid hormone, it also has phosphaturic action.Parathyroid Hormone–Related Protein and HypercalcemiaParathyroid hormone–related protein . . .
Gordon J Strewler (Thu,) studied this question.