Key result
Essential arterial hypertension was associated with significantly higher plasma nitric oxide metabolites and NOS2 gene transcripts, and slightly lower NOS3 mRNA compared to healthy donors.
Why the study?
Are nitric oxide metabolite levels and NOS2/NOS3 gene transcripts altered in patients with essential arterial hypertension compared to healthy donors?
Case-Control
Are nitric oxide metabolite levels and NOS2/NOS3 gene transcripts altered in patients with essential arterial hypertension compared to healthy donors?
Essential arterial hypertension is associated with elevated plasma nitric oxide metabolites and altered NOS2/NOS3 gene expression in peripheral blood leukocytes.
May reflect age- and beta-blocker-related nitric oxide changes in EAH; leaves open biomarker or therapeutic utility pending validation.
It was shown that the level of nitric oxide metabolites in the blood plasma of people with essential arterial hypertension (EAH) is significantly higher than that of healthy donors. This pattern did not depend on the stage of the disease, but on the age of the subjects, as well as on whether patients with cardio-selective β-adrenoreceptor blockers take them or not. It was established that an increase in the level of nitrites and nitrates in the blood of patients with EAH was accompanied by an increase in the level of transcripts of the NOS2 gene in the peripheral blood leukocytes (PBL), while the mRNA content of the NOS3 gene in the PBL patients was slightly lower than that of healthy donors.
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Топчиева et al. (2020) conducted a case-control in Essential arterial hypertension. Essential arterial hypertension vs. Healthy donors was evaluated on Level of nitric oxide metabolites in blood plasma and NOS2/NOS3 gene transcripts. Essential arterial hypertension was associated with significantly higher plasma nitric oxide metabolites and NOS2 gene transcripts, and slightly lower NOS3 mRNA compared to healthy donors.
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