Key result
Endoplasmic reticulum dysfunction drives cardiovascular disease progression through microscopic organelle changes.
The endoplasmic reticulum has an intricate network of pathways built to deal with the secretory and integral membrane protein synthesis demands of the cell, as well as adaptive responses set up for the endoplasmic reticulum to rely on when stressed. These pathways are both essential and complex, and because of these 2 factors, several situations can lead to a dysfunctional endoplasmic reticulum and result in a dysfunctional cell with the potential to contribute to the progression of disease. The endoplasmic reticulum has been implicated in several metabolic, neurodegenerative, inflammatory, autoimmune, and renal diseases and disorders, and in particular, cardiovascular diseases. The role of the endoplasmic reticulum in cardiovascular disease shows how the change in function of a particular microscopic organelle can lead to macroscopic changes in the form of disease.
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Millott et al. (2012) conducted a review in Cardiovascular diseases. Endoplasmic reticulum dysfunction was evaluated. Endoplasmic reticulum dysfunction contributes significantly to the progression of diseases, illustrating how microscopic organelle changes lead to macroscopic cardiovascular disease.
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