Key result
Suppression of phosphoinositide 3-kinase preserved cardiac function and attenuated expression of senescence markers associated with enhanced autophagy in aged mice.
Why the study?
Does suppression of phosphoinositide 3-kinase prevent age-associated molecular changes and preserve cardiac function in aged mice?
Population
Aged mice (murine model of cardiac aging)
Design
Preclinical
Authors
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Suppression of p110α attenuates murine cardiac aging; leaves open whether PI3K inhibition mitigates human cardiac senescence.
Does suppression of phosphoinositide 3-kinase prevent age-associated molecular changes and preserve cardiac function in aged mice?
Suppression of phosphoinositide 3-kinase preserves cardiac function and prevents age-associated molecular changes in a murine model, suggesting a potential molecular target for age-related heart failure.
Inuzuka et al. (2009) studied Cardiac aging. Suppression of the p110alpha isoform of phosphoinositide 3-kinase was evaluated on Cardiac function and expression of senescence markers. Suppression of phosphoinositide 3-kinase preserved cardiac function and attenuated expression of senescence markers associated with enhanced autophagy in aged mice.
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