One Hundred Years after the Discovery of Alzheimer's Disease. A Turning Point for Therapy?

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Key Points

The aim is to evaluate current therapeutic strategies and discuss future directions in Alzheimer's disease treatment.
Review of clinical applications of cholinesterase inhibitors over 20 years.
Assessment of ongoing vaccine trials targeting amyloid-beta in mild-moderate AD patients.
Discussion of experimental therapies including NGF treatment and gene therapy.
Identification of several active and passive vaccines under investigation for efficacy against amyloid-beta.
Emergence of a humanized antibody trial as the most advanced in AD treatment.
Anticipation for new therapies to block disease progression and stabilize patients within the next five to ten years.

This review explores the evolving strategies to modify Alzheimer's disease pathology, indicating a promising shift in therapeutic approaches.

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Giacobini et al. (2007) studied this question.

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