Key result
Preoperative hypertriglyceridemia was associated with a significantly increased risk of postoperative stroke within 30 days in older patients undergoing non-cardiac, non-neurological surgery (adjusted OR 6.618).
Why the study?
The association between hypertriglyceridemia and postoperative stroke remains controversial, particularly in older patients undergoing non-cardiac, non-neurological surgery.
Is preoperative hypertriglyceridemia associated with an increased risk of postoperative stroke in older patients undergoing non-cardiac, non-neurological surgery?
Case-Control (n=110)
No
Is preoperative hypertriglyceridemia associated with an increased risk of postoperative stroke in older patients undergoing non-cardiac, non-neurological surgery?
Preoperative hypertriglyceridemia is associated with a significantly increased risk of postoperative stroke in older patients undergoing non-cardiac, non-neurological surgery.
Hypertriglyceridemia may signal higher postoperative stroke risk in geriatric non-cardiac surgery; hypothesis-generating and requires prospective confirmation before practice change.
Introduction Geriatric postoperative stroke is a rare but serious complication after surgery. The association between hypertriglyceridemia and postoperative stroke remains controversial, especially in older patients undergoing non-cardiac, non-neurological surgery. The study aims to address this clinical dilemma. Materials and methods We conducted a nested case-control study among 9601 aged patients undergoing non-cardiac non-neurological surgery from October 2015 to 2021. A total of 22 positive cases were matched for the surgical type and time, to 88 control patients by a ratio of 1:4. The effect of hypertriglyceridemia on the occurrence of postoperative stroke within 30 days after surgery was estimated using conditional logistic regression analysis by adjusting to various potential confounders. Results A total of 22 cases developed ischemia stroke after surgery, and compared with the non-stroke group, they had more postoperative ICU admission, longer postoperative hospitalization and higher total cost (all p < 0.05), and more patients were presenting with preoperative hypertriglyceridemia [8 (36.4%) vs. 15 (17.0%), p = 0.045]. There was a significant association between hypertriglyceridemia and postoperative stroke, with adjusted odds ratios of 6.618 (95% CI 1.286, 34.064) ( p = 0.024). The above results remained robust in the sensitivity analyses. Conclusion Among older patients undergoing non-cardiac and non-neurological surgery, hypertriglyceridemia was associated with significant increased risk of postoperative stroke.
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Chen et al. (2022) conducted a case-control in Postoperative stroke (n=110). Hypertriglyceridemia vs. Normal triglycerides was evaluated on Postoperative stroke within 30 days (OR 6.618, 95% CI 1.286-34.064, p=0.024). Preoperative hypertriglyceridemia was associated with a significantly increased risk of postoperative stroke within 30 days in older patients undergoing non-cardiac, non-neurological surgery (adjusted OR 6.618).
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