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The noncovalent combination of a supramolecular host with iminium organocatalysis is described. Due to cation-π interactions the reactive iminium species is held inside the host and reacts in this confined environment. The products formed differ up to 92 % ee from the control experiments without added host. A model rationalizing the observed difference is presented.
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Bräuer et al. (2016) studied this question.
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