Key result
Dronedarone exhibits a complex set of electrophysiological and nonelectrophysiological pleiotropic actions that may contribute to its antiarrhythmic effects in patients with atrial fibrillation.
Dronedarone possesses complex pleiotropic actions beyond its primary antiarrhythmic properties that may contribute to its clinical effects in atrial fibrillation.
Dronedarone pleiotropic effects may inform AF drug selection; leaves open their relative contribution to outcomes.
Atrial fibrillation remains the most common arrhythmia in clinical practice. Dronedarone is an antiarrhythmic drug for the maintenance of sinus rhythm in patients with atrial fibrillation. Dronedarone is an amiodarone derivative developed to reduce the number of extracardiovascular side effects. Dronedarone has undergone extensive experimental and clinical testing during the last decade. On the aggregate, these studies have highlighted a complex set of pleiotropic actions that may contribute to dronedarone's antiarrhythmic effects. In this review, we summarize the clinical studies that have evaluated dronedarone and provide an overview of dronedarone's electrophysiological and nonelectrophysiological pleiotropic actions.
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Heijman et al. (2013) conducted a review in Atrial fibrillation. Dronedarone was evaluated. Dronedarone exhibits a complex set of electrophysiological and nonelectrophysiological pleiotropic actions that may contribute to its antiarrhythmic effects in patients with atrial fibrillation.
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