Alkynylation‐Desilylation‐Alkynylation‐Cycloisomerization (ADAC) Three‐Component Synthesis of 2,2′‐Biindolyls – Concise Synthesis of Tjipanazole I

A sequentially Pd/Cu‐catalyzed alkynylation‐desilylation‐alkynylation‐cycloisomerization (ADAC) process in the sense of a consecutive three‐component reaction using TIPS‐butadiyne as a four carbon building block gives a rapid and efficient access to 2,2′‐biindolyls in a one‐pot fashion. This facile entry to unsymmetrically substituted title compounds has been employed in a concise two‐step synthesis of the alga alkaloid tjipanazole I.