A confirmatory trial of hysterectomy with minimal parametrectomy for stage IB1 cervical cancer involving a tumor diameter of 2 cm or less: a Japan Clinical Oncology Group study (JCOG1101)

Takahide Arimoto; Takahiro Kasamatsu; Ryunosuke Machida; Takafumi Toita; Hiroaki Kobayashi; Haruhiko Fukuda; Takashi Onda; Toru Nakanishi; Harushige Yokota; Shoji Kamiura; Kazuhiro Takehara; Hirokuni Takano; Toshiaki Saito; Ikuo Konishi; Satoshi Yamaguchi; Toshiaki Nakamura; Kimio Ushijima; Daisuke Aoki; Nobuo Yaegashi; Toyomi Satoh

doi:10.3802/jgo.2027.38.e8

Key Points

The aim is to assess the efficacy and safety of modified radical hysterectomy in patients with early-stage cervical cancer.
Conducted a prospective, single-arm trial.
Included patients with stage IB1 cervical cancer and tumors ≤2 cm.
Primary endpoint focused on 5-year outcomes.
Preliminary findings indicate positive outcomes for modified radical hysterectomy.
The approach may offer reduced invasiveness compared to standard radical hysterectomy.
Details on 5-year survival rates and specific results will be provided in subsequent analyses.

Implication

Evaluates efficacy and safety of modified radical hysterectomy in cervical cancer, suggesting less invasive options for treatment.

Abstract

Objective:The standard surgery for stage IB uterine cervical cancer is radical hysterectomy (RH).However, RH is highly invasive, and there is a need to establish less invasive techniques.Methods: We conducted a prospective, single-arm trial to evaluate the efficacy and safety of modified radical hysterectomy (MRH)in patients with International Federation of Gynecology and Obstetrics 2008 stage IB1 cervical cancer involving a tumor diameter of ≤2 cm measured on magnetic resonance imaging.The protocol treatment consisted of MRH and adjuvant (chemo)radiotherapy if indicated.The primary endpoint was 5-year

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Cite This Study

Arimoto et al. (2026) studied this question.

synapsesocial.com/papers/6a630062395161722cd154a3 https://doi.org/10.3802/jgo.2027.38.e8

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A confirmatory trial of hysterectomy with minimal parametrectomy for stage IB1 cervical cancer involving a tumor diameter of 2 cm or less: a Japan Clinical Oncology Group study (JCOG1101)

Key Points

Implication

Abstract

Discussion

Cite This Study

A confirmatory trial of hysterectomy with minimal parametrectomy for stage IB1 cervical cancer involving a tumor diameter of 2 cm or less: a Japan Clinical Oncology Group study (JCOG1101)

Key Points

Implication

Abstract

Discussion

Cite This Study

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