Decreased Sphingosine 1-Phosphate Levels in the Prefrontal Cortex of Mice Susceptible to Repeated Social Defeat Stress

Katsuya Morito; Suzumi Kimura; Saki Fujisawa; Yuki Nishimura; Kentaro Takayama

doi:10.1021/acschemneuro.6c00163

July 21, 2026ACS Chemical Neuroscience

Decreased Sphingosine 1-Phosphate Levels in the Prefrontal Cortex of Mice Susceptible to Repeated Social Defeat Stress

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Key Points

This research aims to examine the relationship between sphingosine 1-phosphate levels and social behaviors under stress in mice.
Assessed levels of sphingosine 1-phosphate in the prefrontal cortex of SDS-susceptible mice after 4-day stress exposure.
Analyzed behavioral outcomes related to social avoidance following induced psychosocial stress.
S1P levels were decreased in the prefrontal cortex of mice susceptible to social defeat stress.
Impaired S1P signaling correlated with increased social avoidance behaviors under stress conditions.

Implication

Shows impaired S1P signaling linked to social avoidance in mice after stress exposure, suggesting a physiological connection.

Abstract

were increased in the PFC of 4-day SDS-susceptible mice. These results suggest that impaired S1P signaling in the PFC is associated with the onset of psychosocial stress-induced social avoidance.

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Cite This Study

Morito et al. (2026) studied this question.

synapsesocial.com/papers/6a630062395161722cd154de https://doi.org/10.1021/acschemneuro.6c00163

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Decreased Sphingosine 1-Phosphate Levels in the Prefrontal Cortex of Mice Susceptible to Repeated Social Defeat Stress

Key Points

Implication

Abstract

Discussion

Cite This Study

Decreased Sphingosine 1-Phosphate Levels in the Prefrontal Cortex of Mice Susceptible to Repeated Social Defeat Stress

Key Points

Implication

Abstract

Discussion

Cite This Study

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