Atherosclerotic fatty streaks in human thoracic aortas contained approximately 500% more cholesterol and 45% more phospholipid than adjacent normal intima, with no significant difference in triglyceride content.
Cross-Sectional (n=21)
No
p-value: p=<0.05
The importance of lipids in the pathogenesis of atherosclerosis in man remains obscure, although the accumulation of lipids has long been acknowledged as closely associated with the lesions of the disease. The hypothesis that gross fatty streak lesions occur early in the sequence of pathogenesis provides a significant guide to the study of this disease (1, 2). Comprehensive knowledge about the lipids of the fatty streak lesions would form a firm basis for comparative study of the role lipids play in potentially precursive and successive lesions. At present, the characterization of fatty streak lipids, including their distribution and concentration in arterial tissue, is incomplete. This is due primarily to differences among the published studies in classification of the lesions, methods of tissue sampling, and choice of normal tissue specimens for control analyses. Few analyses have specifically distinguished the lipids of normal intima, normal media, and the fatty streak lesions of atherosclerosis (3-6). This paper reports analyses of cholesterol, phospholipid, and triglyceride in the fatty streak lesions and grossly normal tissues from thoracic aortas of a homogenous group of 11 male subjects and a
Insull et al. (Fri,) conducted a cross-sectional in Atherosclerosis (n=21). Atherosclerotic fatty streak lesions vs. Grossly normal intima and media was evaluated on Concentration of total cholesterol, phospholipid, and triglyceride in fatty streaks compared to normal intima (p=<0.05). Atherosclerotic fatty streaks in human thoracic aortas contained approximately 500% more cholesterol and 45% more phospholipid than adjacent normal intima, with no significant difference in triglyceride content.