Dinuclear Zinc(II) Complexes as Metallo-β-Lactamase Inhibitors with Antibiofilm Activity against MDR Gram-Negative Bacteria

Samik Biswas; Sujan Sk; Sangita Das; Soma Mondal; S. Ali; Supratim Mandal; Manindranath Bera

doi:10.1021/acsabm.6c00501

July 22, 2026ACS Applied Bio Materials

Dinuclear Zinc(II) Complexes as Metallo-β-Lactamase Inhibitors with Antibiofilm Activity against MDR Gram-Negative Bacteria

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Key Points

To investigate the efficacy of dinuclear zinc(II) complexes as inhibitors of metallo-β-lactamase in multidrug-resistant (MDR) bacteria.
Characterization of dinuclear zinc(II) complexes as metallo-β-lactamase inhibitors.
Assessment of antibiofilm activity against MDR Gram-negative bacteria.
Dinuclear zinc(II) complexes significantly inhibit metallo-β-lactamases in tested strains.
Higher antibiofilm activity observed, indicating potential for treating MDR infections.

Implication

Evaluates dinuclear zinc complexes targeting metallo-β-lactamase in MDR bacteria, suggesting a new treatment approach.

Abstract

could emerge as an MBL inhibitor confronting MDR bacterial infections and medicinal implant-associated maladies as a significant therapeutic alternative over conventional antibacterial treatment regimens.

Discussion

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Cite This Study

Biswas et al. (2026) studied this question.

synapsesocial.com/papers/6a6301a6395161722cd1639e https://doi.org/10.1021/acsabm.6c00501

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Dinuclear Zinc(II) Complexes as Metallo-β-Lactamase Inhibitors with Antibiofilm Activity against MDR Gram-Negative Bacteria

Key Points

Implication

Abstract

Discussion

Cite This Study

Dinuclear Zinc(II) Complexes as Metallo-β-Lactamase Inhibitors with Antibiofilm Activity against MDR Gram-Negative Bacteria

Key Points

Implication

Abstract

Discussion

Cite This Study

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