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July 24, 2026MedCommOpen Access

Precision Stereotactic Body Radiotherapy for Ultra‐Central NSCLC: Tailored Margins Reduce Toxicity Without Compromising Tumor Control

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Authors

DLDi LiuSYShuangyan YangYCYun Chen

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Overview

Retrospective study shows tailored margins reduce toxicity in ultra-central NSCLC, indicating improved safety for treatment.

Key Points

  • This study aims to evaluate the effectiveness and safety of tailored stereotactic body radiation therapy margins for ultra-central NSCLC.
  • Retrospective analysis of 66 patients with stage I–II unresectable ultra-central NSCLC from 2020 to 2023.
  • Utilized tailored SBRT plans with non-uniform planning target volume margins in 45.5% of cases.
  • Evaluated outcomes including progression-free survival, local control, and overall survival rates.
  • Median progression-free survival was 42.9 months; 1-year PFS rate was 93.9%.
  • 1-year local control rate was 98.5% with overall survival rates of 98.5% at 1 year.
  • Only one case of grade 3 pneumonitis was observed, indicating manageable toxicity.

Cite This Study

Liu et al. (2026) studied this question.

synapsesocial.com/papers/6a630255395161722cd16a55https://doi.org/10.1002/mco2.70589
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1SWOG/NRG S1914: Randomized phase III trial of induction/consolidation atezolizumab + SBRT versus SBRT alone in high risk, early-stage NSCLC.2025 · 20 citations
  2. 2Excessive Toxicity When Treating Central Tumors in a Phase II Study of Stereotactic Body Radiation Therapy for Medically Inoperable Early-Stage Lung Cancer2006 · 1,557 citations
  3. 3Practice Patterns of Spatially Fractionated Radiation Therapy: A Clinical Practice Survey2023 · 44 citations
  4. 4Spatially fractionated radiation therapy: History, present and the future2019 · 209 citations