Mortality in Patients With Hodgkin Lymphoma and Heart Failure

Figures

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  Figure 1. Standardized Overall Survival∗ With 95% CIs Survival after incident heart failure (HF) among patients previously diagnosed with classical Hodgkin lymphoma (cHL) and matched lymphoma-free comparators. Point-wise estimates with uncertainty are given in the accompanying table below. ∗ Predicted from a flexible parametric nonproportional hazards model (with 3 degrees of freedom (df) for the baseline rate and 2 for the time-dependent effect), adjusted for all matching variables: Age and year of HF diagnosis, sex, and source of HF (inpatient/outpatient register). Age and year were modeled assuming nonlinear effects, using restricted cubic splines with 4 df. The effect of exposure to cHL was allowed to vary between sex and age by including interaction terms. Standardized overall adjustment variables. cHL = classical Hodgkin lymphoma; HF = heart failure.

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  Figure 2. Covariate-Specific Standardized Overall Survival∗ Survival among males (top panel) and females (bottom panel) aged 60 (left) and 80 (right) at heart failure (HF) diagnosis in patients with a previous classical Hodgkin lymphoma (cHL) and matched comparators. Point-wise estimates with uncertainty are given in the accompanying table below. ∗ Predicted from a flexible parametric nonproportional hazards model (with 3 degrees of freedom (df) for the baseline rate and 2 for the time-dependent effect), adjusted for all matching variables: Age and year of HF diagnosis, sex, and source of HF (inpatient/outpatient register). Age and year were modeled assuming nonlinear effects, using restricted cubic splines with 4 df. The effect of exposure to cHL was allowed to vary between sex and age by including interaction terms. Standardized over calendar year and source of HF. Abbreviations as in Figure 1.

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  Central Illustration. Mortality in Heart Failure Patients With and Without Hodgkin Lymphoma CV = cardiovascular; other abbreviations as in Figure 1.