Made-to-order: We discuss modified oligonucleotides and mimics that have been developed with improved physicochemical and biological properties, and utilised in a wide range of applications. New conjugation strategies have been developed to aid delivery and cellular localisation. Modified oligonucleotides are also widely used as probes for bioanalytical applications and as building blocks for assembly of higher-order nanostructures.
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Bell et al. (2009) studied this question.
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