Key result
The thrombodynamics test, unlike standard hemostasis tests, can assess the prothrombotic status of patients with atrial fibrillation for personalized selection of anticoagulant therapy.
Why the study?
The study evaluated the possibility of using the thrombodynamics test compared with standard hemostasis tests to monitor anticoagulant therapy in non-valvular AF patients with left atrial appendage thrombosis.
Does the thrombodynamics test improve the assessment of prothrombotic status compared to standard hemostasis tests in patients with non-valvular AF and LAA thrombosis?
Case Report
Does the thrombodynamics test improve the assessment of prothrombotic status compared to standard hemostasis tests in patients with non-valvular AF and LAA thrombosis?
The thrombodynamics test may offer advantages over standard hemostasis tests for personalizing anticoagulant therapy in patients with non-valvular AF who develop LAA thrombosis despite DOAC therapy.
Switching anticoagulants may alter hemostatic parameters in AF with LAA thrombus; leaves open TD's utility versus standard tests.
Clinical observations of the possibility of using the thrombodynamics test (TD) in comparison with standard hemostasis tests in patients with non-valvular atrial fibrillation (AF) and detected thrombosis of the left atrial appendage against the background constant oral anticoagulants are presented. It has been shown that the transfer from one direct oral anticoagulant (DOACs) to another (with a different mechanism of action), as well as from DOACs to warfarin, can change the state of the blood plasma coagulation system towards both hyper- and hypocoagulation. Unlike standard hemostasis tests, TD can be used to assess the prothrombotic status of a patient with AF and personalized selection of effective anticoagulant therapy.
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Khorkova et al. (2025) conducted a case report in Non-valvular atrial fibrillation with left atrial appendage thrombosis. Thrombodynamics test vs. Standard hemostasis tests was evaluated on Assessment of prothrombotic status and personalized selection of effective anticoagulant therapy. The thrombodynamics test, unlike standard hemostasis tests, can assess the prothrombotic status of patients with atrial fibrillation for personalized selection of anticoagulant therapy.
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