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May 11, 2012PLoS ONEOpen Access

The Role of TNF-α in Mice with Type 1- and 2- Diabetes

Maria Koulmanda Manoj Bhasin Zuheir L. Awdeh Andi Qipo Zhigang Fan Dusan Hanidziar Prabhakar Putheti Hang Shi Eva Csizuadia Towia A. Libermann Terry B. Strom

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Key Points

The study aims to identify TNF-α as a potential therapeutic target in improving diabetes treatment outcomes.
Used genome-wide transcriptional profiling and bioinformatics analysis on NOD mice.
Examined impacts of Power Mix and alpha1 antitrypsin treatments on pancreatic lymph node and fat tissues.
Applied short-term anti-TNF-α treatment to assess effects on immune response and insulin signaling.
Anti-TNF-α treatment improved beta cell viability and enhanced immune tolerance to beta cells.
Restoration of insulin signaling and improved insulin sensitivity were observed post-treatment.
TNF-α was identified as a central hub gene, interacting notably with genes linked to diabetes reversal.

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Implication

Examines TNF-α's role in diabetes management, indicating new therapeutic targets.

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Cite This Study

Koulmanda et al. (2012) studied this question.

synapsesocial.com/papers/6a6315d384b8043778288c41 https://doi.org/10.1371/journal.pone.0033254

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