Key result
Epicardial adipose tissue acts as a highly active organ producing adipokines and cytokines, contributing to increased cardiovascular morbidity and mortality in hemodialysis patients.
Why the study?
Cardiovascular diseases remain the primary cause of morbidity and mortality in hemodialysis patients, and epicardial adipose tissue has emerged as a novel cardiovascular risk factor.
What is the role of epicardial adipose tissue in the pathophysiological mechanisms of increased cardiovascular morbidity and mortality in hemodialysis patients?
What is the role of epicardial adipose tissue in the pathophysiological mechanisms of increased cardiovascular morbidity and mortality in hemodialysis patients?
Epicardial adipose tissue acts as a highly active endocrine organ that contributes to the increased cardiovascular risk observed in patients with chronic kidney disease and those undergoing hemodialysis.
EAT may refine CV risk assessment in hemodialysis; leaves open its clinical utility and need for prospective validation.
Cardiovascular diseases remain the most common cause of morbidity and mortality in chronic kidney disease patients undergoing hemodialysis. Epicardial adipose tissue (EAT), visceral fat depot of the heart, was found to be associated with coronary artery disease in cardiac and non-cardiac patients. Additionally, EAT has been proposed as a novel cardiovascular risk in the general population and in end-stage renal disease patients. It has also been shown that EAT, more than other subcutaneous adipose tissue deposits, acts as a highly active organ producing several bioactive adipokines, and proinflammatory and proatherogenic cytokines. Therefore, increased visceral adiposity is associated with proinflammatory activity, impaired insulin sensitivity, increased risk of atherosclerosis, and high morbidity and mortality in hemodialysis patients. In the present review, we aimed to demonstrate the role of EAT in the pathophysiological mechanisms of increased cardiovascular morbidity and mortality in hemodialysis patients.
No takes yet. Share an insight, caveat, or question.
Türkmen et al. (2022) conducted a review in Chronic kidney disease and hemodialysis. Epicardial adipose tissue (EAT) was evaluated on Cardiovascular morbidity and mortality. Epicardial adipose tissue acts as a highly active organ producing adipokines and cytokines, contributing to increased cardiovascular morbidity and mortality in hemodialysis patients.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: