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Directed evolution of the nonheme iron enzyme isopenicillin N synthase (IPNS) produces a highly efficient biocatalyst that enables the enantiodivergent synthesis of l- and d-arylglycines via a new-to-nature 1,3-nitrogen migration mechanism. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.ESTABLISHES_NEW_DIRECTION.

Nonheme Fe Enzyme‐Catalyzed Enantiodivergent Nitrogen Migration: Directed Evolution and Computational Study of Isopenicillin N Synthases for Biocatalytic Synthesis of Arylglycines

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