Key result
Alpha-MHC gene expression in the murine lung is first detectable between 13.9-14.3 days post-coitum and progresses through the neonatal period, exhibiting an atrial pattern.
The study demonstrates that murine pulmonary myocardium exhibits an atrial pattern of cardiac-specific gene expression, which extends into the lung during development, likely via migration of atrial myoblasts.
Hypothesis-generating for atrial myoblast migration into lung; leaves open any human translational relevance.
Long-standing observations that cardiac muscle exists in the walls of the pulmonary and caval veins have recently been confirmed at the molecular level (Lyons et al. [1990] J. Cell Biol. 111:2427-2436; Springall et al. [1988] Thorax 43:44-52; Subramaniam et al. [1991] J. Biol. Chem. 266:24613-24620). Using ventricle- and atrial-specific riboprobes, we determined that the pulmonary myocardium exhibits an atrial pattern of cardiac-specific gene expression. Additionally, the developmental pattern of expression was studied using a riboprobe specific to the alpha-cardiac myosin heavy chain (alpha-MHC) gene transcript. We find that alpha-MHC gene expression is first detectable in the lung between 13.9-14.3 days post-coitum. Extension of the alpha-MHC specific hybridization signal into the pulmonary venous bed progresses through the neonatal period. The data are consistent with the hypothesis that the extension of alpha-MHC gene expression into the lung occurs via the migration of atrial myoblasts into the vein during atrial septation and remodeling of the sinus venosus and pulmonary venous trunk.
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Jones et al. (1994) studied this question. Alpha-MHC gene expression in the murine lung is first detectable between 13.9-14.3 days post-coitum and progresses through the neonatal period, exhibiting an atrial pattern.
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