Key result
C-reactive protein is a strong but nonspecific risk factor for a broad range of outcomes including fatal stroke, coronary heart disease, cancer, and total mortality in elderly persons.
The article in this issue by Gussekloo et al,1 “C-reactiveprotein is a strong but nonspecific risk factor of fatal strokein elderly persons, ” demonstrates 2 important points. First, for maximum predictive value, a variable such as C-reactive protein (CRP) should preferably be a risk factor for a specific outcome rather than for a broad range of unrelated outcomes such as stroke, coronary heart disease, cancer, and total mortality. There are some risk factors such as cigarette smoking and radiation exposure that are associated with many different outcomes, and future work may
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Kuller et al. (2000) conducted an editorial in Cardiovascular Disease. C-reactive protein (CRP) was evaluated. C-reactive protein is a strong but nonspecific risk factor for a broad range of outcomes including fatal stroke, coronary heart disease, cancer, and total mortality in elderly persons.
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