What question did this study set out to answer?

To assess COVID-19-related and cardiovascular disease (CVD)-related mortality and examine demographic and regional disparities in deaths attributed to both conditions.

July 24, 2026Journal of the American College of CardiologyOpen Access

CDC-WONDER Database Analysis of COVID-19 and Cardiovascular Disease-Related Mortality

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To assess COVID-19-related and cardiovascular disease (CVD)-related mortality and examine demographic and regional disparities in deaths attributed to both conditions.
Retrospective analysis of CDC-WONDER database mortality records from January 1, 2020, to December 31, 2021, among US adults aged ≥25 years.
Identified deaths attributed to COVID-19 (ICD-10 code U07.1), diseases of the circulatory system (ICD-10 codes I00-I99), or both as underlying or contributing causes.
Calculated age-adjusted mortality rates (AAMRs) per 100,000 population standardized to the year 2000 US population, stratified by age, sex, race/ethnicity, and census region.
Among 6,715,183 total deaths, 385,462 were related to both COVID-19 and CVD, yielding an overall AAMR of 73.2 (95% CI: 73.0-73.4) per 100,000.
Mortality from both conditions was highest in elderly adults aged ≥65 years (AAMR: 284.8; 95% CI: 283.8-285.9) and in men compared to women (AAMR: 93.6 vs 56.7).
Significant racial disparities occurred, with the highest AAMR in Hispanic (117.7; 95% CI: 116.7-118.6) and non-Hispanic Black individuals (114.5; 95% CI: 113.6-115.5) compared to non-Hispanic White (61.6; 95% CI: 61.4-61.9) and Asian individuals (51.5; 95% CI: 50.7-52.4).

Implication

Database analysis reveals high mortality and racial disparities from concurrent COVID-19 and cardiovascular disease in US adults, highlighting persistent inequities.

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Cite This Study

Maqsood et al. (2023) studied this question.

synapsesocial.com/papers/6a634f45186db6d1cccf0de2 https://doi.org/10.1016/j.jacc.2023.02.044

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Implication

Database analysis reveals high mortality and racial disparities from concurrent COVID-19 and cardiovascular disease in US adults, highlighting persistent inequities.

CDC-WONDER Database Analysis of COVID-19 and Cardiovascular Disease-Related Mortality

Key Points

Implication

Discussion

Cite This Study

CDC-WONDER Database Analysis of COVID-19 and Cardiovascular Disease-Related Mortality

Key Points

Implication

Discussion

Cite This Study

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