Key result
Human urotensin II drives vascular smooth muscle contraction and proliferation via RhoA/Rho-kinase activation.
The aim of this work was to investigate the coupling of human urotensin II (hU-II) to RhoA activation and regulation of RhoA-dependent functions. The use of the Rho-kinase inhibitor Y-27632 and the development of a membrane-permeant RhoA inhibitor (TAT-C3) allowed us to demonstrate that hU-II induced arterial smooth muscle contraction, actin stress fiber formation, and proliferation through the activation of the small GTPase RhoA and its downstream effector Rho-kinase.
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Sauzeau et al. (2001) studied this question. Human urotensin II (hU-II) and RhoA inhibitors (Y-27632, TAT-C3) was evaluated on Arterial smooth muscle contraction, actin stress fiber formation, and proliferation. Human urotensin II induces arterial smooth muscle contraction, actin stress fiber formation, and proliferation through the activation of the small GTPase RhoA and its downstream effector Rho-kinase.
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