Answers are grounded in this paper and cite their sources.
Evaluates oxadiazole antibacterials' efficacy in MRSA infections, suggesting strong potential for new treatments.
A structure–activity relationship (SAR) for the oxadiazole class of antibacterials was evaluated by syntheses of 72 analogs and determination of the minimal-inhibitory concentrations (MICs) against the ESKAPE panel of bacteria. Selected compounds were further evaluated for in vitro toxicity, plasma protein binding, pharmacokinetics (PK), and a mouse model of methicillin-resistant Staphylococcus aureus (MRSA) infection. Oxadiazole 72c shows potent in vitro antibacterial activity, exhibits low clearance, a high volume of distribution, and 41% oral bioavailability, and shows efficacy in mouse models of MRSA infection.
No takes yet. Share an insight, caveat, or question.
Boudreau et al. (2019) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: