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A new method for the meta -arylation of pyridine N -oxides that employs o -diiodobenzene derivatives as convenient aryne precursors is reported. In contrast to the Kobayashi precursors, o -diiodobenzenes are either commercially available or readily prepared from simple starting materials and generate arynes under mild conditions via NaH-mediated activation. Our approach not only significantly expands the substrate scope of pyridine N -oxides but also offers an operationally simpler and complementary route to 3-arylpyridines.
Ouyang et al. (Fri,) studied this question.