Key result
The DENOVA score yielded a significantly higher area under the ROC curve (0.95) than the NOVA score (0.91) for identifying infective endocarditis in monomicrobial Enterococcus faecalis bacteremia.
Why the study?
Does the DENOVA score improve the identification of infective endocarditis compared to the NOVA score in patients with monomicrobial Enterococcus faecalis bacteremia?
Cohort (n=614)
Yes
Does the DENOVA score improve the identification of infective endocarditis compared to the NOVA score in patients with monomicrobial Enterococcus faecalis bacteremia?
Absolute Event Rate: 0.95% vs 0.91%
p-value: p=0.001
The DENOVA score is a highly sensitive and more specific tool than the NOVA score for ruling out infective endocarditis in patients with Enterococcus faecalis bacteremia, potentially reducing unnecessary transesophageal echocardiograms.
No takes yet. Share an insight, caveat, or question.
DENOVA may aid endocarditis detection in E. faecalis bacteremia; leaves open need for prospective validation versus NOVA.
Berge et al. (2018) conducted a cohort in Monomicrobial Enterococcus faecalis bacteremia (n=614). DENOVA score vs. NOVA score was evaluated on Area under the ROC curve (AUC) for identifying infective endocarditis (95% CI 0.94-0.97, p=0.001). The DENOVA score yielded a significantly higher area under the ROC curve (0.95) than the NOVA score (0.91) for identifying infective endocarditis in monomicrobial Enterococcus faecalis bacteremia.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: