The intramolecular aryl-aryl coupling reaction of phenyl benzoate derivatives is a convenient method for construction of a 6H-dibenzo [b,d] pyran-6-one skeleton which is frequently found in natural products. Palladium reagents are used for the C-C bond formation between two aromatic rings. This review article describes that this technique is effective for the syntheses of several natural products possessing a highly oxygenated 6H-dibenzo [b,d] pyran-6-one core. The regioselectivity in the reaction is also discussed with some transition state illustrations. For further application, asymmetric construction of the biphenyl moiety is presented using the dynamic kinetic optical resolution method.
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Hitoshi Abe (2017) studied this question.
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