Nonsense-mediated mRNA decay involves Upf factors providing several functions during premature termination, with ultimate mRNA degradation being the last step in the process.
This review proposes a unified model for nonsense-mediated mRNA decay where mRNA degradation is the final step in a complex premature termination process involving Upf factors.
Nonsense-mediated mRNA decay (NMD) is a eukaryotic surveillance mechanism that monitors cytoplasmic mRNA translation and targets mRNAs undergoing premature translation termination for rapid degradation. From yeasts to humans, activation of NMD requires the function of the three conserved Upf factors: Upf1, Upf2, and Upf3. Here, we summarize the progress in our understanding of the molecular mechanisms of NMD in several model systems and discuss recent experiments that address the roles of Upf1, the principal regulator of NMD, in the initial targeting and final degradation of NMD-susceptible mRNAs. We propose a unified model for NMD in which the Upf factors provide several functions during premature termination, including the stimulation of release factor activity and the dissociation and recycling of ribosomal subunits. In this model, the ultimate degradation of the mRNA is the last step in a complex premature termination process.
He et al. (Mon,) conducted a review in Nonsense-mediated mRNA decay. Nonsense-mediated mRNA decay (NMD) was evaluated. Nonsense-mediated mRNA decay involves Upf factors providing several functions during premature termination, with ultimate mRNA degradation being the last step in the process.
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