What is the clinical evidence from this study?

Study design: Other. Population: Chronic aortic stenosis. Intervention: Phospholamban-knockout vs. Isogenic wild-type mice. Primary outcome: Cardiac decompensation and left ventricular hypertrophy.

What question did this study set out to answer?

The aim is to evaluate the capacity of phospholamban-knockout hearts to withstand chronic aortic stenosis compared to wild-types.

February 1, 2002Cardiovascular ResearchOpen Access

Hypertrophy and functional alterations in hyperdynamic phospholamban-knockout mouse hearts under chronic aortic stenosis

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Key result

Hyperdynamic phospholamban-knockout mouse hearts compensated against sustained aortic stenosis similarly to wild-type mice, with comparable development of left ventricular hypertrophy.

Why the study?

Does phospholamban knockout alter the ability of mouse hearts to withstand chronic aortic stenosis compared to wild-type?

Population

Phospholamban-knockout mice and isogenic wild-type mice

Comparison

Transverse aortic banding vs Sham-operated mice

Design

Preclinical

Follow-up

10 weeks

Authors

HKHelen KiriazisHeart Failure & Transplant

Discussion

Member takes

Implication

PLB-KO fails to prevent decompensation in murine pressure overload; leaves open whether PLB targeting benefits human HF.

Key Points

The aim is to evaluate the capacity of phospholamban-knockout hearts to withstand chronic aortic stenosis compared to wild-types.
Aortic banding was performed on phospholamban-knockout and wild-type mice along with sham-operated controls.
Echocardiography was used to assess cardiac function before and 2.5, 5, and 10 weeks post-surgery.
Heart failure incidence was similarly observed in both knockout and wild-type groups, linked to higher pre-surgery heart rates.
Left ventricular hypertrophy development was equivalent between knockouts and wild-types, with dilation noted in failing mice.
Fractional shortening decreased similarly in both genotypes, with an earlier onset in failing knockouts.

Structured PICO

Does phospholamban knockout alter the ability of mouse hearts to withstand chronic aortic stenosis compared to wild-type?

Population

Phospholamban-knockout and isogenic wild-type mice subjected to transverse aortic banding and followed for up to 10 weeks.

Exposure

Transverse aortic banding (chronic aortic stenosis model)

Comparator

Sham-operated mice

Outcome

Cardiac decompensation (lung congestion), left ventricular hypertrophy, end-diastolic dimension, fractional shortening, ejection times, and SR Ca(2+)-ATPase protein levelssurrogate

Phospholamban knockout does not impair the ability of the mouse heart to compensate for chronic pressure overload induced by aortic banding.

Cite This Study

Helen Kiriazis (2002) studied Chronic aortic stenosis. Phospholamban-knockout vs. Isogenic wild-type mice was evaluated on Cardiac decompensation and left ventricular hypertrophy. Hyperdynamic phospholamban-knockout mouse hearts compensated against sustained aortic stenosis similarly to wild-type mice, with comparable development of left ventricular hypertrophy.

synapsesocial.com/papers/6a6398cb3eb69703d1b72885 https://doi.org/10.1016/s0008-6363(01)00487-4

Topics

Echocardiography

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Hypertrophy and functional alterations in hyperdynamic phospholamban-knockout mouse hearts under chronic aortic stenosis

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Hypertrophy and functional alterations in hyperdynamic phospholamban-knockout mouse hearts under chronic aortic stenosis

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

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