Article AbstractLetter to the Editor Sir: Sexual dysfunction is a common and troubling side effect of serotonin reuptake inhibitors (SRIs). The incidence of sexual dysfunction associated with SRIs has been estimated to be as high as 34%. The mechanism underlying sexual dysfunction associated with SRIs has not been fully characterized, but is thought to be partly mediated by direct serotonergic effects.
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Nelson et al. (1997) studied this question.
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