Key result
Peptides targeting the helicase activity of enterovirus protein 2C demonstrated broad-spectrum antiviral potential against enteroviruses, including coxsackievirus B3 and echovirus 11.
Peptides targeting the 2C helicase activity show promise as broad-spectrum antivirals against enteroviruses.
Should not change clinical practice; hypothesis-generating for 2C helicase inhibitors in human enteroviral disease.
Furthermore, we demonstrate that the strategy of targeting the 2C helicase activity can be used for other relevant enteroviruses, including coxsackievirus B3 and echovirus 11. In summary, our findings provide compelling evidence that the designed peptides targeting the helicase activity of 2C could be broad-spectrum antivirals for enteroviruses.
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Fang et al. (2021) studied this question. Peptides targeting the helicase activity of enterovirus protein 2C demonstrated broad-spectrum antiviral potential against enteroviruses, including coxsackievirus B3 and echovirus 11.
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