Erythrocyte P2X1 receptor expression is correlated with change in haematocrit in patients admitted to the ICU with blood pathogen-positive sepsis
Authors
Discussion
Loading...
Member takes
Implication
Randomized trial uncovers the link between P2X receptor levels and haematocrit changes in patients with sepsis, suggesting new treatment avenues.
Key Points
- To examine the relationship between P2X receptor expression in blood cells and changes in haematocrit during sepsis.
- Analyzed blood samples for P2X 1 and P2X 7 receptor abundance using flow cytometry at ICU admission.
- Grouped patients by blood pathogen presence after ED admission for correlation assessment.
- Found an inverse correlation between P2X 1 expression and change in haematocrit (rs − 0.80) and haemoglobin (rs − 0.78) in pathogen-positive patients.
- P2X 1 expression was significantly higher in patients exhibiting greater decreases in haematocrit (−0.59 ± 0.36) and haemoglobin (−0.182 ± 0.038 mg/dl) per hour.
Cite This Study
Fagerberg et al. (2018) studied this question.