Mechanistic Studies on Direct Arylation of Pyridine N-Oxide: Evidence for Cooperative Catalysis between Two Distinct Palladium Centers

Direct arylations of pyridine N-oxide (PyO), a convenient method to prepare 2-arylpyridines, catalyzed by Pd(OAc)(2) and PtBu(3) have been proposed to occur by the generation of a PtBu(3)-ligated arylpalladium acetate complex, (PtBu(3))Pd(Ar)(OAc) (1), and the reaction of this complex with PyO. We provide strong evidence that 1 does not react directly with PyO. Instead, our data imply that the cyclometalated complex Pd(OAc)(tBu(2)PCMe(2)CH(2))(2), which is generated from the decomposition of 1, reacts with PyO and serves as a catalyst for the reaction of PyO with 1. The reaction of PyO with 1 occurs with an induction period, and the reaction of 1 with excess PyO in the presence of Pd(OAc)(tBu(2)PCMe(2)CH(2))(2) is zeroth-order in 1. Moreover, the rates of reactions of PyO with bromobenzene catalyzed by Pd(OAc)(tBu(2)PCMe(2)CH(2))(2) and Pd(PtBu(3))(2) depend on the concentration of Pd(OAc)(tBu(2)PCMe(2)CH(2))(2) but not on the concentration of Pd(PtBu(3))(2). Finally, the reaction of 1 with a model heteroarylpalladium complex containing a cyclometalated phosphine, (PEt(3))Pd(2-benzothienyl)(tBu(2)PCMe(2)CH(2)), rapidly formed the arylated heterocycle. Together, these data imply that the rate-determining C-H bond cleavage occurs between PyO and the cyclometalated Pd(OAc)(tBu(2)PCMe(2)CH(2))(2) rather than between PyO and 1. In this case, the resulting heteroarylpalladium complex transfers the heteroaryl group to 1, and C-C bond-formation occurs from (PtBu(3))Pd(Ar)(2-pyridyl oxide). This mechanism proposed for the direct arylation of PyO constitutes an example of C-H bond functionalization in which C-H activation occurs at one metal center and the activated moiety undergoes functionalization after transfer to a second metal center.