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Experimental and theoretical methods demonstrate how trivalent cations regulate ion transport in nanochannels, suggesting new control mechanisms.
Ion-induced regulation in the body bears an important body control responsibility, making it one of the most important control mechanisms for ion channels. In this work, we use experimental and theoretical methods to mimic the possible regulation process induced by multivalent ions in an artificial calcium-responsive nanochannel (ACRN). Cerium, whose properties are similar to those of calcium, is introduced as the invasive factor. This trivalent cation can lead to a charge inversion of the inner wall of the ACRN and thus change the ion transport state from cation selectivity to anion selectivity. When both Ce3+ and Ca2+ coexist in the solution, they can change the ionic transport behaviors of the channel synergistically. Calcein is used to functionalize the nanochannel to form the ACRN. The change of surface charge is the key reason to regulating the ion transport and is confirmed by theoretical calculation with the Poisson/Nernst–Plank model.
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Wang et al. (2018) studied this question.
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