Why the study?
Guidelines recommend defibrillation testing during S-ICD implantation, but many physicians omit it due to complication risks and contradictory retrospective safety data.
Does defibrillation testing during subcutaneous implantable cardioverter-defibrillator (S-ICD) implantation improve safety or efficacy compared to its omission?
Does defibrillation testing during subcutaneous implantable cardioverter-defibrillator (S-ICD) implantation improve safety or efficacy compared to its omission?
The necessity of defibrillation testing during S-ICD implantation remains controversial with contradicting retrospective data, highlighting the need for ongoing randomized trials to guide clinical practice.
Since the publication of the SIMPLE and NORDIC trials, defibrillation testing (DFT) is rarely performed during routine implantation of transvenous implantable cardioverter-defibrillators (ICD). However, the results of these trials cannot be extrapolated to the later introduced subcutaneous ICD (S-ICD) and a class I recommendation to perform DFT during the implantation of these devices remains in the current guidelines. Due to the high conversion success rate of DFT on one hand, and the risk of complications on the other, a significant number of physicians omit DFT in S‑ICD recipients. Several retrospective analyses have assessed the safety of the omission of DFT and report contradicting results and recommendations. It is known that implant position, as well as device factors and patient characteristics, influence defibrillation success. A better comprehension of these factors and their relationship could lead to more reliable and safer alternatives to DFT. An ongoing randomised clinical trial, which is expected to end in 2023, is the first study to implement a method that assesses implant position to identify patients who are likely to fail their DFT.
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Stuijt et al. (2020) conducted a review in Ventricular arrhythmias and high risk of sudden cardiac death requiring S-ICD. Defibrillation testing (DFT) vs. Omission of DFT was evaluated. Routine defibrillation testing during subcutaneous implantable cardioverter-defibrillator implantation remains a class I recommendation but is increasingly omitted due to complication risks, pending ongoing trial results.
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