Key result
Depression independently increased the risk of mortality by 43% (HR 1.43) over 11 years in older adults with moderate hypertension, even after adjusting for cardiovascular risk factors and cognitive decline.
Cohort (n=2,584)
Yes
Hazard Ratio: 1.43 (95% CI 1.03–1.98)
p-value: p=0.040
May warrant depression screening in older hypertensive adults; leaves open whether treatment reduces mortality.
Background It is not clear whether the increased mortality associated with depression can be explained by the effects of potential confounding variables.
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Abas et al. (2002) conducted a cohort in Moderate hypertension (n=2,584). Depression vs. No depression was evaluated on Mortality (HR 1.43, 95% CI 1.03-1.98, p=0.040). Depression independently increased the risk of mortality by 43% (HR 1.43) over 11 years in older adults with moderate hypertension, even after adjusting for cardiovascular risk factors and cognitive decline.
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