Key result
A 59-year-old man with diabetes on long-term hemodialysis developed progressive cardiac hypertrophy and complete atrioventricular block, which autopsy confirmed as mitochondrial cardiomyopathy.
Case Report (n=1)
No
Mitochondrial cardiomyopathy warrants consideration in early diabetes with LVH and conduction block; leaves open optimal screening in m.3243A>G carriers.
A 59-year-old man developed diabetes at 24 years old and underwent hemodialysis at 42 years old. At 54 years old, cardiac dysfunction with left ventricular hypertrophy was detected, followed by complete atrioventricular block at 57 years old. The patient was diagnosed with mitochondrial disease based on a myocardial biopsy and the presence of a mitochondrial DNA mutation (3243A>G). He died of septic shock at 59 years old, and an autopsy confirmed mitochondrial cardiomyopathy. If progressive cardiac hypertrophy and conduction disturbances are observed in patients with diabetes mellitus on long-term hemodialysis, mitochondrial disease needs to be considered.
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Ochiai et al. (2023) conducted a case report in Mitochondrial cardiomyopathy and maternally inherited diabetes with deafness (n=1). Mitochondrial disease (3243A>G mutation) was evaluated on Clinical and autopsy findings of cardiomyopathy. A 59-year-old man with diabetes on long-term hemodialysis developed progressive cardiac hypertrophy and complete atrioventricular block, which autopsy confirmed as mitochondrial cardiomyopathy.
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