Mitochondrial Ca²⁺ channels: Great unknowns with important functions

Mitochondria process local and global Ca(2+) signals. Thereby the spatiotemporal patterns of mitochondrial Ca(2+) signals determine whether the metabolism of these organelles is adjusted or cell death is executed. Mitochondrial Ca(2+) channels of the inner mitochondrial membrane (IMM) actually implement mitochondrial uptake from cytosolic Ca(2+) rises. Despite great efforts in the past, the identity of mitochondrial Ca(2+) channels is still elusive. Numerous studies aimed to characterize mitochondrial Ca(2+) uniport channels and provided a detailed profile of these great unknowns with important functions. This mini-review revisits previous research on the mechanisms of mitochondrial Ca(2+) uptake and aligns them with most recent findings.