Key result
Thyroid hormones are important modulators of metabolic processes, energy balance, and the browning of white adipose tissue, with relevance to cardiovascular and metabolic disease progression.
This review summarizes the mechanisms by which thyroid hormones regulate metabolic processes, particularly focusing on their role in the 'browning' of white adipose tissue and relevance to cardiovascular and metabolic diseases.
May inform metabolic research in thyroid disease; leaves open whether browning modulation alters cardiovascular outcomes.
Thyroid hormones (THs) are important modulators of many metabolic processes, being strictly associated with the control of energy balance, mainly through activities on the brain, white and brown adipose tissue, skeletal muscle, liver, and pancreas. In this review, the principal mechanisms of TH regulation on metabolic processes will be discussed and THs' relevance in metabolic disease progression will be evaluated, especially in the cardiovascular context and correlated diseases. Moreover, we will discuss THs' regulatory role on metabolic events in white and brown adipose tissue, with a special focus on the process of "browning", which consists of the gradual acquisition by white adipocytes of the physical and functional characteristics of brown adipocytes. The advancements in research on molecular mechanisms and proposed physiopathological relevance of this process will be discussed.
No takes yet. Share an insight, caveat, or question.
Sabatino et al. (2025) conducted a review in Metabolic and cardiovascular diseases. Thyroid hormones was evaluated. Thyroid hormones are important modulators of metabolic processes, energy balance, and the browning of white adipose tissue, with relevance to cardiovascular and metabolic disease progression.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: