Key result
Co-administration of loratadine and amiodarone in a 73-year-old woman resulted in syncope and multiple episodes of Torsades de pointes.
Why the study?
Does co-administration of loratadine and amiodarone cause Torsades de Pointes and QT prolongation?
Case Report (n=1)
Does co-administration of loratadine and amiodarone cause Torsades de Pointes and QT prolongation?
Co-administration of loratadine with QT-prolonging drugs like amiodarone may cause Torsades de Pointes and warrants QT interval monitoring.
May prompt QT monitoring with loratadine-amiodarone co-use; leaves open interaction prevalence and need for prospective confirmation.
ATAR, S., et al.: Torsades de Pointes and QT Prolongation Due to a Combination of Loratadine and Amiodarone. Torsades de pointes (TdP) has not been previously reported with loratadine. A 73‐year old woman on chronic treatment with amiodarone for atrial fibrillation received loratadine and presented with syncope and multiple episodes of TdP. We suggest that QT interval should be monitored whenever loratadine is co‐administered with drugs that may potentially prolong QT. (PACE 2003; 26:785–786)
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Atar et al. (2003) conducted a case report in Atrial fibrillation (n=1). Loratadine and Amiodarone combination was evaluated on Syncope and Torsades de pointes. Co-administration of loratadine and amiodarone in a 73-year-old woman resulted in syncope and multiple episodes of Torsades de pointes.
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