Key points are not available for this paper at this time.
The enantioselective intramolecular addition of silyl enol ethers and silyl ketene aminals onto alkyne is described. The reaction employs DTBMSegphos−Pd(II) or Binaphane−Pd(II) complexes as catalysts for the formation of methylene cyclopentane adducts from 1,6-enyne precursors. The utility of this reaction is illustrated by its application to the total synthesis of the cytotoxic cyclolaurane-type sesquiterpene, (−)-laurebiphenyl.
Corkey et al. (Sat,) studied this question.