Key result
Baseline coronary artery calcium score > 10 was associated with an increased risk of major adverse cardiovascular events in persons with type 1 diabetes without kidney disease (p=0.04).
Why the study?
Persons with type 1 diabetes have an increased cardiovascular disease risk even without kidney disease, so this study evaluated whether arterial calcification can augment CV risk stratification.
Does increased coronary artery calcium score predict future major adverse cardiovascular events in persons with type 1 diabetes without kidney disease?
Cohort (n=75)
Does increased coronary artery calcium score predict future major adverse cardiovascular events in persons with type 1 diabetes without kidney disease?
p-value: p=0.04
Increased coronary artery calcium score (CACS > 10) predicts future major adverse cardiovascular events in patients with long-term type 1 diabetes without kidney disease, suggesting a role for CACS in individualized CV risk management.
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May aid CV risk stratification in type 1 diabetes without kidney disease; leaves open whether it alters outcomes or practice.
Hjortkjær et al. (2025) conducted a cohort in Type 1 diabetes without kidney disease (n=75). Arterial calcification (baseline CACS > 10) vs. CACS ≤ 10 was evaluated on Major adverse CV events (MACE) defined as CV-death, ischemic heart disease, heart failure, stroke, coronary interventions, and/or peripheral artery intervention (p=0.04). Baseline coronary artery calcium score > 10 was associated with an increased risk of major adverse cardiovascular events in persons with type 1 diabetes without kidney disease (p=0.04).
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