Mitochondrial metabolism influences meiotic maturation in human oocytes of young and advanced maternal age women

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Impaired mitochondrial metabolism compromises the meiotic progression of human oocytes, contributing to the reduced maturation capacity observed in women of advanced maternal age. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.NEUTRAL.

Sara Pietroforte; Marion Martins; Montserrat Barragán; Elena Ibáñez; Rita Vassena; Mina Popovic; Tim Sanchez; Denny Sakkas; Filippo Zambelli

doi:10.1093/humrep/deaf207

November 6, 2025Human Reproduction

Mitochondrial metabolism influences meiotic maturation in human oocytes of young and advanced maternal age women

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Key Points

This study aims to investigate the relationship between mitochondrial metabolism and meiotic progression in oocytes from young and advanced maternal age women.
Analyzed 340 germinal vesicle (GV) oocytes from 34 young and 37 advanced maternal age women
Used fluorescence lifetime imaging microscopy (FLIM) for metabolic assessment and immunofluorescence for mitochondrial activity
Oocytes matured in vitro and assessed for meiotic progression via polar body extraction
AMA oocytes showed significantly lower mitochondrial activity (D-LAT intensity 12,517 ± 10,187 AU) compared to young oocytes (D-LAT intensity 78,614 ± 58,534 AU, P = 0.003)
Redox ratio indicating metabolism was lower in AMA oocytes (1.00 ± 0.16) than in young oocytes (2.00 ± 0.15, P = 2.969e-05)
Maturation rates were lower in AMA oocytes (62.3% maturation) versus young oocytes (86.3% maturation, P = 0.002)

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Implication

Shows mitochondrial activity affects meiotic progression in young and advanced maternal age women, suggesting aging impacts oocyte quality.

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Cite This Study

Pietroforte et al. (2025) studied this question.

synapsesocial.com/papers/6a64027594fed506997235ea https://doi.org/10.1093/humrep/deaf207

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Mitochondrial metabolism influences meiotic maturation in human oocytes of young and advanced maternal age women

Key Points

No abstract yet

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Implication

Discussion

Cite This Study

Mitochondrial metabolism influences meiotic maturation in human oocytes of young and advanced maternal age women

Key Points

No abstract yet

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Implication

Discussion

Cite This Study

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