Key result
Recent acute ischaemic stroke or TIA was not associated with a significant difference in forearm flow mediated dilatation compared to stable cerebrovascular disease (mean paired difference 1.25%, p=0.18).
Why the study?
Does recent acute ischaemic stroke or TIA impair systemic vascular function (measured by FMD) compared to stable cerebrovascular disease?
Case-Control (n=34)
Yes
Does recent acute ischaemic stroke or TIA impair systemic vascular function (measured by FMD) compared to stable cerebrovascular disease?
Mean Difference: 1.25 (95% CI -0.65–3.14)
Absolute Event Rate: 6% vs 4.7%
p-value: p=0.18
Recent acute ischaemic stroke or TIA is not associated with a clinically important reduction in systemic vascular function as measured by forearm flow-mediated dilatation when compared to stable cerebrovascular disease.
No FMD difference after acute versus stable cerebrovascular events; leaves open endothelial function's role in secondary stroke risk stratification.
BACKGROUND: Acute ischaemic stroke is associated with alteration in systemic markers of vascular function. We measured forearm vascular function (using forearm flow mediated dilatation) to clarify whether recent acute ischaemic stroke/TIA is associated with impaired systemic vascular function. METHODS: Prospective case control study enrolling 17 patients with recent acute ischaemic stroke/TIA and 17 sex matched controls with stroke more than two years previously. Forearm vascular function was measured using flow medicated dilatation (FMD). RESULTS: Flow mediated dilatation was 6.0 ± 1.1% in acute stroke/TIA patients and 4.7 ± 1.0% among control subjects (p = 0.18). The mean paired difference in FMD between subjects with recent acute stroke and controls was 1.25% (95% CI -0.65, 3.14; p = 0.18). Endothelium independent dilatation was measured in six pairs of participants and was similar in acute stroke/TIA patients (22.6 ± 4.3%) and control subjects (19.1 ± 2.6%; p = 0.43). CONCLUSIONS: Despite the small size of this study, these data indicate that recent acute stroke is not necessarily associated with a clinically important reduction in FMD.
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Etherton‐Beer et al. (2010) conducted a case-control in Acute ischaemic stroke or TIA (n=34). Recent acute ischaemic stroke or TIA vs. Stable cerebrovascular disease (stroke/TIA >2 years previously) was evaluated on Forearm flow mediated dilatation (FMD) (Mean paired difference 1.25%, 95% CI -0.65, 3.14, p=0.18). Recent acute ischaemic stroke or TIA was not associated with a significant difference in forearm flow mediated dilatation compared to stable cerebrovascular disease (mean paired difference 1.25%, p=0.18).
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