February 6, 2008Molecular TherapyOpen Access

Targeted Migration of Mesenchymal Stem Cells Modified With CXCR4 Gene to Infarcted Myocardium Improves Cardiac Performance

Q: What is the clinical evidence from this study?

Study design: Other. Population: Myocardial infarction. Intervention: Intravenous infusion of CXCR4-overexpressing mesenchymal stem cells (CXCR4-MSCs) vs. Saline or unmodified MSCs. Primary outcome: Left ventricular function and remodeling.

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Key result

Intravenous delivery of CXCR4-overexpressing mesenchymal stem cells in rats post-myocardial infarction improved homing to the infarct region and preserved left ventricular function at 30 days.

Why the study?

Does intravenous delivery of CXCR4-overexpressing MSCs improve cardiac performance and cell homing in rats with myocardial infarction?

Population

Rats with myocardial infarction induced by coronary occlusion/reperfusion

Comparison

Intravenous infusion of retrovirally transduced… vs Saline or unmodified MSCs

Design

Preclinical

Follow-up

30 days

Authors

ZCZhaokang ChengWashington State University Spokane LOLailiang OuNankai University XZXin ZhouChinese Academy of Sciences

Discussion

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Implication

May support non-invasive CXCR4-MSC infusion post-MI; extends homing-based stem cell strategies in cardiac repair research.

Structured PICO

Does intravenous delivery of CXCR4-overexpressing MSCs improve cardiac performance and cell homing in rats with myocardial infarction?

Population

Rats subjected to coronary occlusion and reperfusion, followed for 30 days post-myocardial infarction.

Intervention

Intravenous infusion of retrovirally transduced mesenchymal stem cells (MSCs) constitutively expressing CXCR4 (CXCR4-MSCs) delivered 24 hours after coronary occlusion/reperfusion

Comparator

Saline or unmodified MSCs

Outcome

Homing of cells to the infarct region, LV chamber dimensions, anterior wall thinning, collagen I/III ratio, and LV function recovery at 30 dayssurrogate

Intravenous delivery of CXCR4-overexpressing MSCs improves cell homing and post-infarction cardiac performance in a rat model of myocardial infarction.

Cite This Study

Cheng et al. (2008) studied Myocardial infarction. Intravenous infusion of CXCR4-overexpressing mesenchymal stem cells (CXCR4-MSCs) vs. Saline or unmodified MSCs was evaluated on Left ventricular function and remodeling. Intravenous delivery of CXCR4-overexpressing mesenchymal stem cells in rats post-myocardial infarction improved homing to the infarct region and preserved left ventricular function at 30 days.

synapsesocial.com/papers/6a64a58fb261e609d338efa9 https://doi.org/10.1038/sj.mt.6300374

Topics

Echocardiography

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Targeted Migration of Mesenchymal Stem Cells Modified With CXCR4 Gene to Infarcted Myocardium Improves Cardiac Performance

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Targeted Migration of Mesenchymal Stem Cells Modified With CXCR4 Gene to Infarcted Myocardium Improves Cardiac Performance

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider