Key result
Bilateral microinjection of an NMDA receptor antagonist in the LTF abolished cardiac-related power and coherence of sympathetic nerve discharge to the arterial pulse in cats.
NMDA receptor-mediated neurotransmission in the medullary lateral tegmental field is critical for baroreceptor reflex control of sympathetic nerve discharge.
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LTF blockade disrupts baroreflex indexes in cats; leaves open its role in human SND control.
Orer et al. (1999) studied this question. Bilateral microinjection of NMDA and non-NMDA receptor antagonists in the LTF was evaluated on Cardiac-related power in sympathetic nerve discharge (SND), coherence of SND to the arterial pulse, and inhibition of SND during increased arterial pressure. Bilateral microinjection of an NMDA receptor antagonist in the LTF abolished cardiac-related power and coherence of sympathetic nerve discharge to the arterial pulse in cats.
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