Population
Stat1 knock-out mice (Stat1(-/-)) and immunocompetent wild-type (WT) control mice (suckling and adult)
Comparison
Oral infection with rotavirus or vaccination… vs Immunocompetent (WT) mice or unimmunized controls
Design
Preclinical
Follow-up
2-6 days after infection
Key result
Loss of Stat1 in adult mice resulted in up to 100-fold more rotavirus shedding compared to wild-type mice, but did not impair viral clearance or protection against subsequent challenge.
Authors
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Animal data on Stat1 and rotavirus warrant no practice change; leaves open its role in human innate immunity and clearance.
Loss of Stat1 causes a defective innate immune response in adult mice leading to increased viral shedding, but does not impair eventual viral clearance or protection against subsequent rotavirus challenge.
VanCott et al. (2003) studied Rotavirus infection. Stat1 knock-out (loss of IFN function) vs. Immunocompetent wild-type mice was evaluated on Rotavirus shedding and diarrhea. Loss of Stat1 in adult mice resulted in up to 100-fold more rotavirus shedding compared to wild-type mice, but did not impair viral clearance or protection against subsequent challenge.