Key result
Exposure to rotavirus NSP4 induced a humoral IgG response in 100% of naturally infected children and adults, and a cellular immune response in 80% of tested adults.
Why the study?
Does rotavirus NSP4 stimulate humoral and cellular immune responses in humans?
Population
40 individuals including naturally infected children, rotavirus-vaccinated children, and adults
Design
Cross-sectional
Authors
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Supports NSP4 immunogenicity across groups; hypothesis-generating for rotavirus vaccine targets.
Observational (n=40)
Does rotavirus NSP4 stimulate humoral and cellular immune responses in humans?
Rotavirus NSP4 induces both humoral and cellular immune responses in humans, suggesting its role as an immunogenic enterotoxin.
Johansen et al. (1999) conducted an observational in Rotavirus infection (n=40). Rotavirus infection or vaccination (NSP4 exposure) was evaluated on Humoral and cellular immune responses to recombinant NSP4. Exposure to rotavirus NSP4 induced a humoral IgG response in 100% of naturally infected children and adults, and a cellular immune response in 80% of tested adults.
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