Key result
Fetal growth retardation is linked to similar spiral artery lesions regardless of maternal hypertension status.
Observational (n=80)
Answers are grounded in this paper and cite their sources.
Uteroplacental spiral arteries in placental bed biopsies and placentas form 80 pregnancies were studied by light and electron microscopy; of these 30 were complicated by fatal growth retardation(less than 10th centile) and 45 by hypertension during pregnancy. The physiological changes of the spiral arteries and the vascular pathology present in hypertensive pregnancy and fetal growth retardation were investigated. In normotensive pregnancies complicated by fetal growth retardation, the physiological changes of pregnancy frequently did not extend beyond the decidual segments of the utero-placental arteries. In pregnancies complicated by pre-eclampsia, the physiological changes of pregnancy were not always restricted to the decidual segments of the utero-placental arteries. Atheromatous-like lesions of similar morphology were found in spiral arteries from both normotensive and hypertensive pregnancies complicated by fetal growth retardation. No arteriopathy was found which was specific for pre-eclampsia.
No takes yet. Share an insight, caveat, or question.
Sheppard et al. (1981) conducted an observational in Hypertensive pregnancy and fetal growth retardation (n=80). Hypertension and fetal growth retardation vs. Normotensive pregnancies was evaluated on Physiological changes of the spiral arteries and vascular pathology. Fetal growth retardation in both normotensive and hypertensive pregnancies was associated with similar atheromatous-like lesions in spiral arteries, with no arteriopathy specific to pre-eclampsia.
Synapse has enriched 10 related papers. Consider them for comparative context: